Flight prices from Chicago to Santa Cruz de la Sierra

There’s no fixed price — fares between Chicago and Santa Cruz can vary a lot by day or time.

Choose a date to explore the best fares now.

The lowest fares are often found with some flexibility in travel dates. If your plans are flexible, you’ll have a better chance of finding cheap flights.

Is there more than one airport in Chicago or Santa Cruz?

Even short-haul routes can benefit from considering secondary airports. It may open up more flight times or cheaper fares.

• Airports in Chicago: Chicago has 3 airports - Midway, O'Hare, Rockford.
• Airports in Santa Cruz: Santa Cruz is another arrival option.

Airports with more daily flights offer more flexibility if plans change or delays occur. If you’re flexible, consider airports near Santa Cruz as well.

Adjust your flight filters for Chicago – Santa Cruz de la Sierra

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Other popular destinations

Planning a trip to Bolivia? These cities are popular too: Cochabamba, La Paz, Santa Cruz, Sucre, Tarija.

Sorting options let you see the most affordable flights first. Some results may include extra fees shown only at checkout — always read carefully to see what’s included.